Isorhamnetin help

BitterDB id=885
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Roland WS, van Buren L, Gruppen H, Driesse M, Gouka RJ, et al. (2013). Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39. J Agric Food Chem 61(44): 10454-66. PubMed 24117141
[2] URL link
[3] Roland W. S. U. et al. Bitter Taste Receptor Activation by Flavonoids and Isoflavonoids: Modeled Structural Requirements for Activation of hTAS2R14 and hTAS2R39, J. Agric. Food Chem., 2013, 61, 44, 10454–10466 PubMed 24117141
[4] Yang Q. et al. Comprehensive identification of non-volatile bitter-tasting compounds in Zanthoxylum bungeanum Maxim. by untargeted metabolomics combined with sensory-guided fractionation technique, Food Chemistry, 2021, 347, 129085 PubMed 33493837
[5] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 125.0 PubMed:24117141
Human  hTas2r14 125.0 PubMed:36871162
Human  hTas2r14 125.0 PubMed:33493837
Human  hTas2r39 0.12 PubMed:24117141
Human  hTas2r39 0.12 PubMed:36871162

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

316.2700 [g/mol] 2.29100
4 7
3 3
2

Identifiers: help

480-19-3
C16H12O7
IZQSVPBOUDKVDZ-UHFFFAOYSA-N

Links:

[1] 5281654
[2] ZINC000000517261