Chloroquine 
BitterDB id=87 , Synthetic
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422 | |
| [3] | Freund J. R. et al. Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling, Journal of Biological Chemistry, 2018, 293, 25, 9824-9840 PubMed 29748385 | |
| [4] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [5] | Ziegler F. and Behrens M. Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions in vitro, Proceedings of the Royal Society B: Biological Sciences, 2021, 288(1947) PubMed 33784867 | |
| [6] | Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956 | |
| [7] | Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711 | |
| [8] | Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835 | |
| [9] | Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References | Sequence variant |
|---|---|---|---|---|
hTas2r3 |
10.0 | PubMed:20022913 | ||
|
hTas2r3 |
172.0 | PubMed:24266887 | ||
|
hTas2r3 |
10000.0 | PubMed:34785711 | ||
|
hTas2r7 |
10000.0 | PubMed:34785711 | ||
|
hTas2r10 |
10000 | PubMed:20022913 | ||
|
hTas2r14 |
10.0 | PubMed:20022913 | ||
|
hTas2r39 |
100.0 | PubMed:20022913 | AAM19321.1 | |
ggTas2r1 |
1000.0 | PubMed:25180257 | ||
mTas2r115 |
100 | PubMed:27226572 | ||
droTas2r1 |
10000.0 | PubMed:33784867 | ||
|
droTas2r4 |
10000.0 | PubMed:33784867 | ||
|
droTas2r7 |
3000.0 | PubMed:33784867 | ||
lchTas2r1 |
10000.0 | PubMed:33355666 | ||
|
dreTas2r1 |
10000.0 | PubMed:33355666 | ||
|
dreTas2r3a |
10000.0 | PubMed:33355666 | ||
|
ccarpTas2r200-1 |
1000.0 | PubMed:34504956 | ||
tgTas2r5 |
PubMed:37860623 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 319.8800 [g/mol] | 4.81060 |
| 1 | 3 |
| 2 | 2 |
| 8 | |
| 330 [mg/kg B.W.] |
Identifiers:
| 54-05-7 |
| C18H26ClN3 |
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| WHTVZRBIWZFKQO-UHFFFAOYSA-N |
Links:
| [1] | 2719 | |||
| [2] | ZINC000019144226 | ZINC000019144231 | ||
| [3] | DB00608 | |||
| [4] | 5535 |
