L-trp, L-tryptophan help

BitterDB id=827 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Kohl S, Behrens M, Dunkel A, Hofmann T, Meyerhof W (2013). Amino acids and peptides activate at least five members of the human bitter taste receptor family. J Agric Food Chem 61(1): 53-60. PubMed 23214402
[2] Kohl S. et al. Amino Acids and Peptides Activate at Least Five Members of the Human Bitter Taste Receptor Family, Journal of Agricultural and Food Chemistry, 2013, 61 (1), 53-60 PubMed 23214402
[3] Jiang D. and Peterson D. G. Identification of bitter compounds in whole wheat bread, Food Chemistry, 2013, 141, 2, 1345-1353 PubMed 23790923
[4] Delompre T. et al. Taste Perception of Nutrients Found in Nutritional Supplements: A Review, Nutrients, 2019, 11(9), 2050 PubMed 31480669
[5] Gunther-Jordanland K. Quantitation and Taste Contribution of Sensory Active Molecules in Oat (Avena sativa L.), Journal of Agricultural and Food Chemistry, 2020, 68 (37), 10097-10108 PubMed 32786831
[6] Junger M. Sensoproteomic Discovery of Taste-Modulating Peptides and Taste Re-engineering of Soy Sauce, Journal of Agricultural and Food Chemistry, 2022, 70 (21), 6503-6518 PubMed 35593506
[7] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[8] Sonntag T, Kunert C, Dunkel A, Hofmann T (2010). Sensory-guided identification of N-(1-methyl-4-oxoimidazolidin-2-ylidene)-alpha-amino acids as contributors to the thick-sour and mouth-drying orosensation of stewed beef juice. J Agric Food Chem 58(10): 6341-50. PubMed 20420435

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 PubMed:31480669
Human  hTas2r4 10000.0 PubMed:23214402
Human  hTas2r39 PubMed:31480669
Human  hTas2r43 PubMed:31480669
Human  hTas2r49 PubMed:31480669

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 5.0 [mM] Reference
Bitter recognition threshold 5.0 [mM] Reference
Bitter recognition threshold 5.0 [mM] Reference
Bitter recognition threshold 5 [mM] Reference

Properties: help

204.2300 [g/mol] 1.12230
3 2
2 2
3

Identifiers: help

73-22-3,80206-30-0
C11H12N2O2
QIVBCDIJIAJPQS-VIFPVBQESA-N
L-Trp

Links:

[1] 6305
[2] ZINC000000083315
[3] DB00150
[4] 717