Methimazole help

BitterDB id=115 , Synthetic
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302
[3] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[4] Nguyen H. et al. Thiazolidinediones are partially effective bitter blockers, bioRxiv, 2023 PubMed 37609224
[5] URL link

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r38 30 PubMed:20022913
Cat  fcTas2r7 10000.0 PubMed:26488302

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 2.111 [mM] Reference

Properties: help

114.1700 [g/mol] 1.08269
1 2
1 1
0

Identifiers: help

13431-10-2,60-56-0,85916-84-3
C4H6N2S
PMRYVIKBURPHAH-UHFFFAOYSA-N

Links:

[1] 1349907
[2] ZINC000001187543
[3] DB00763
[4] 6649