hTAS2R16 - Taste receptor type 2 member 16
- chr7:122,634,759-122,635,754 UCSC
- 33,986 (Da)
MIPIQLTVFFMIIYVLESLTIIVQSSLIVAVLGREWLQVR RLMPVDMILISLGISRFCLQWASMLNNFCSYFNLNYVLCN LTITWEFFNILTFWLNSLLTVFYCIKVSSFTHHIFLWLRW RILRLFPWILLGSLMITCVTIIPSAIGNYIQIQLLTMEHL PRNSTVTDKLENFHQYQFQAHTVALVIPFILFLASTIFLM ASLTKQIQHHSTGHCNPSMKARFTALRSLAVLFIVFTSYF LTILITIIGTLFDKRCWLWVWEAFVYAFILMHSTSLMLSS PTLKRILKGKC
Please scroll down to see the rest of the ligands.
Download SDF file of selected compounds.
When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper
Known Mutations Table
|E86||TM3||3.33||E86D||Reduced response to salicin, large reduction in its response to arbutin and phenyl-β-D-glucopyranoside|||
|E86Q||Reduced response to salicin|
|N89||TM3||3.36||N89Q||Lost receptor responsivenes to salicin|||
|F93||TM3||3.40||F93T||Greatly reduced response to salicin|||
|W94||TM3||3.41||W94F||Small difference in receptor responsiveness to Salicin|||
|W94I||Significantly decrease in receptor responsiveness to salicin|
|Q177||TM5||5.39||Q177N||Not significantly affected the receptor activity by salicin|||
|H181||TM5||5.43||H181T||small decrease in receptor responsiveness to salicin||Interaction with ligands|
|H181L||Significantly decrease in receptor responsiveness to salicin|
|F240||TM6||6.51||F240Y||Reduced response to salicin|||
|F240L||Greatly reduced response to salicin|
|F240W||Reduced response to salicin|
|I243||TM6||6.54||I243L||Mild reduced response to salicin|||
|I243V||Mild reduced response to salicin|
|I243A||Greatly reduced response to salicin|
 Sakurai, T. et al. (2010) Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16,, The Journal of biological chemistry, 285, 28373-8.